I think as long as you keep in mind the volume of water you're modifying, you're fine. If you add them to the MT (or really you could just add them to your strike and sparge water as well) then you are adding enough to raise both your strike and sparge water - so you have to add enough to get to the ppm you need for that amount of water. If adding to the boil, you add enough based on what you're finished volume is - 5 gallons or whatever. If you add to finished beer just realize that the salt will drive off some of the carbonation, so that is also going to change the flavor as well. It may be difficult to determine if the difference in flavor is a result of sulfate/chloride or carbonation differences, but I think it's worth playing around with.This gives me an idea - if you added 5 tablespoons of epsom salt to 5 gallons of ale - you might be able to market it as a detoxification/colon cleaning beer. That seems to be all the rage now a days...Thanks Joe. Yeah, I was actually having a similar conversation about that this morning and the other part of it is that more of the salts will make it into the primary if they're added to the brewpot than they would if they were added to the MT, apparently.
