I took out a couple nests. Like Dagomike said, dual wielding is key. I mixed up some permethrin in a 2 gallon garden sprayer and pressurized it. That was my left handed weapon, intended to make the next uninhabitable. In my right hand I had some hornet spray. I started spraying into the nest with my left hand, hitting it with the long lasting permethrin and flooding the nest. When hornets started to come out, they were slowed and confused by the permethrin, and I nailed them with the bifenthrin spray. I didn't get stung at all while taking out the nest.
Another tactic I've heard about is to stick the suction hose of a wet/dry vac in the nest, retreat, then plug in the vacuum (assuming you already have the switch in the "on" position). Any bees who attack the vac get sucked up, cutting down on the number of soldiers when you later go in double-wielding.